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Aga Hair ProductsNizoral study Ized image analysis (MOP Videoplan Kontron, Eching, Germany) was applied to the same samples to derive the average diameter (1), pm) of the hair shafts at 1.5 cm from the bulb.Both hair variables employed are known to decrease during AGA progression.Hence, an AGA pilary index (PI) was derived to combine these variables following PI= AxD.Seborrhea is often present in AGA [14] and fuels growth of lipophilic rnicroorganisms.It is therefore not desirable for both biological and cosmetic reasons.The sebum casual level at the skin surface was measured at each evaluation time using the Sebumetee (Courage and Khazaka, Cologne, Germany).Four measurements were taken at random on the alopecic vertex and the average was calculated.There was a treatment-free interval of at least 36 h between the last shampoo and sebumetric measurements.Study 2 In light of the data yielded by the first study, a comparison was made between effects of KCZ and minoxidil on the AGA hair status.Two groups of 4 men, aged between 24 and 29 years, who showed grade III vertex AGA, were selected after giving their informed consent. A 4-mm punch biopsy was taken from the vertex area at inclusion in the study and after a 6-month treatment using either the 2% KCZ shampoo (Nizoral) or the combination of 2% minoxidil lotion (Rogame', Upjohn) once daily and the unmedicated shampoo Wash and Go.Shampoos were used ad libitum.Biopsies were formalin-fixed and paraffin-embedded.Step sections were cut parallel to the skin surface.Computerized image analysis (MOP Videoplan Kontron) was applied to the section where the sebaceous glands had the largest relative area. For each pilary unit, both the hair shaft diameter and the sebaceous gland area were recorded.Statistical Analysis The distribution of each variable was characterized by the median, 95% confidence interval and mode.When the distribution was normal, the mean (M), standard deviation (SD) and the coefficient of variation (V = 102 SID - M-') were calculated.Group differences at entry in the study were compared statistically employing the Mann-Whitney U test for unpaired samples.Variance (ANOVA) and regression model analyses were applied to determine the relationship between variables. All results were considered to be significant at the 5% critical level.Results Study I At entry in the study, subjects with AGA had a significantly lower PI (p0.001) than controls (fig.1).No significant difference was then found between PI of the two AGA subgroups.In control subjects without AGA, the PI remained unchanged during the study, whether they used the KCZ or the unmedicated shampoo.The PI of AGA subjects using the unmedicated shampoo showed a slow linear (r=0.56, p0.05) decrease in time (fig.1).Large interindividual diherences were evidenced in the AGA evolution as evaluated by the PI. In contrast to such a disease progression, the KCZ group yielded a progressive PI increase that became evident after a 6-month survey and apparently reached a plateau value after about 15 months (fig.1).However, the overall relationship between KCZ PI and time was best fitted by a linear regression model (r= 0.69, p 0.01).The mean sebum casual level was sig-nificantly (p0.05) higher in AGA subjects (11547 pg/cm') than in controls (6944 pg/em').It did not show any evidence for meaningful variation in AGA and normal volunteers using the unmedicated shampoo.A trend in logarithmic decrease (r=-0.43, p0.07) was found in KCZ-treated AGA subjects, reaching a median reduction of 18% at the completion of the study.Study 2 At entry into the study, the AGA hair den-sity reached 250--t38/CM2 in the KCZ group and 276 33/cM2 in the minoxidil + unmed-icated shampoo group.No significant dif-ference in both hair shaft diameter and seba-ceous gland area was present between the two allocated groups receiving one of the Fig.1.Variations in time of the PI (median and 95% confidence interval) in subjects with AGA.The use of 2% KCZ shampoo (E) is associated with a significant increase in PI, while the natural evolution of the alopecia on unmedicated shampoo (0) shows a slow progressive decrease in Pl.0, 0 = 95 % confidence intervals. Values in nonalopecic subjects (N) are presented by the 10th and 90th percentile boundaries. Fig.2.Negative linear relationships between hair shaft diameter and area of sebaceous glands in AGA.a=Before KCZ treatment (n=r=-0.46, slope=-0.52, p0.01); b=after a 6-month KCZ treatment (n=149, r=-0.42, slope= -0.39, p0.01); c=before minoxidil+unmedicated shampoo treatment (n= 144, r=-0.65, slope= -0.63, p0.01); d=aftera6-month minoxidil+unmedicated shampoo treatment (n= r=-0.54, slope= -0.54, p0.01).. Fig.3.Median and 95% confidence interval of the hair shaft di-ameter in AGA: evaluations before (TO) and after a 6-month treatment J6) using either 2% KCZ shampoo or a combination of minoxidil with an unmedicated shampoo. Fig.4.Mean and standard deviation of the sebaceous gland area in AGA: evaluations before (TO) and after a 6-month treatment (T6) using either 2% KCZ shampoo or a combination of minoxidil with an unmedicated shampoo. two treatments. The median hair shaft diameter was 46.7 gm (confidence interval: 29.6-71.8).The distribution of that hair variable was bimodal in most AGA subjects. The intraindividual coefficients of variation ranged from 3 2 to 6 8 %.A normal di stribution of sebaceous gland area was found with a mean of 1,614491 pm'.In both subgroups of subjects, a negative linear relationship was found between the hair shaft diameter and the area of the corresponding sebaceous glands (fig.2).At completion of the 6-month trial, the hair density reached 296 22/cm' (+ 18%) in the KCZ group and 306 29/CM2 (+11%) in the minoxidil + unmedicated shampoo group.A 7% increase in the median hair shaft diameter was yielded by both the KCZ shampoo and minoxidil + unmedicated shampoo combination (fig 
.Proprietary blend extracts 100% Veggie Capsule No smelly solutions No animal by-products naturally sourced, cost-effective alternative to painful transplants and expensive drugs.One capsule per day is all it takes to put you on the road to STOPPING HAIR LOSS!Safe, Simple, NaturalSafe, Simple, NaturalSTOPS HAIR LOSS!STOPS HAIR LOSS!Biofen ShampooTMBioFen REVITALIZING SHAMPOO contains a unique formulation of pure botanical extracts designed to nourish and protect hair and scalp Our formula contains none of the potentially harmful Lauryl/Laureth Sulfate ingredients; we only use potent vegetable based cleansing TMagents.BioFen REVITALIZING SHAMPOO is an extremely gentle yet effective shampoo formulated to remove harmful chemical buildup on hair and scalp which is often the cause for hair loss.The optimal pH of 5.5 corresponds to the natural pH of healthy skin and scalp.Precious oils and vitamins stabilize the integrity of the hair and protects the hair while building y day.Biofen Conditioner TMBioFen STIMULATING CONDITIONER contains generous amounts of pure botanical extracts designed to nourish and protect hair t and work hours after the hair treatment resulting in a wonderful tingling sensation.All natural moisturizing agents give the hair excellent manageability with shine, strength , look more radiant and be easier to manage. By providing , resistance to environmental damage is significantly increased giving hair .Regular usage will leave the hair healthy and full of life.TMGentle enough for every day use. BioFen Conditioner contains no artificial colors or a period of time, an over abundance of DHT causes the hair follicle to degrade and shortens the active phase of the hair, eventually leading to thinner hair and eventual hair loss.TMHow does BIO-FEN PLUS work?Specific compounds within the herbal extracts inhibit the 5-alpha-ugs such as Propecia (finasteride) work. , BIO-FEN TMPLUS also contains additional compounds which remove excess .TMBIO-FEN PLUS also contains vitamins to increase blood flow to BIO-TMFEN PLUS provides a natural, safer alternative to expensive drugs, and/or expensive & natives, results vary from person to person, and no one product will work for everyone.TMHow long must I use BIO-FEN PLUS?TMBIO-FEN PLUS capsules are usually effective at stopping hair loss within the first two months.However, since healthy hair grows only about 1 cm each month, it may take up to three months before you ther hair loss is stopped.Anyone experiencing new growth will see it within four to six months. BIO-TMFEN PLUS supplement dose to one capsule every second or every TMthird day.Some clients will continue to take BIO-FEN PLUS daily. Once you stop completely, however, your hair growth pattern will slowly go back to the point where you Men & Women of All Ages!For Men & Women of All PLUS is a natural health product used in the treatment of hereditary androgenic alopecia (AGA) in adults (male or female pattern baldness.) It contains scientifically calculated proportions of extracts of fenugreek seeds, saw palmetto berries and flax lignans.Each are known to possess an inhibitor of the enzyme responsible for causing male or n baldness. It also contains a mixture of B vitamins, folate and biotin to help metabolize these herbal extracts so that they are more t the growth of strong and healthy hair.What causes hereditary hair loss?Each hair grows from a pocket in the skin called the hair follicle.During mal papilla.The papilla is fed by very small blood vessels, which bring it food & oxygen and remove wastes. The papilla is mones and chemicals secreted by the body (or ingested as a medicine) which impacts hair growth.It is believed that monal changes caused by an enzyme in the dermal papilla called 5-alpha-reductase.This enzyme breaks down the hormone testosterone into dihydrotestosteroneTM How safe is BIO-FEN PLUS?TMThe ingredient combination in BIO-FEN PLUS is generally safe for most adults. However, the following cautions are advised: Folic acid: Consult a health care practitioner if you are uncertain whether or not you are taking adequate vitamin B12, as folate supplementation can mask a Vitamin B12 deficiency.Vitamin B3: Consult a health care practitioner prior to use if you have impaired liver function.Vitamin B6: Consult a health care practitioner prior to use if you are taking levodopa.TMWhat is the quality of BIO-FEN PLUS ?TMBIO-FEN PLUS is manufactured in Canada according to a quality assurance program called Good Manufacturing Practices (GMP).This ensures that the ingredients are tested for their level of quality, potency & purity, prior to production and again prior to sale.See our website to locate your nearest Health Food Store or Pharmacy that offers BIO-FEN TMPLUS and other quality products from Hair Grow Technology.If you have any questions or comments about our products that target hair loss and support the growth of strong, healthy hair, please do not hesitate to contact us.We believe TMBIO-FEN PLUS is the only natural Health Product application for the treatment of AGA (Male and Female Pattern Baldness) submitted for approval by Health Canada.as at August 4th,2005.Each TMBIO-FEN PLUScapsule contains (mg/capsule):Recommended adult dose: one capsule per dayFenugreek (Trigonella feonum graecum)seed extract 4:1 .............................260 mgSaw palmetto berry extract contains45% powder, esters & sterols...................160 mgFlax lignans, standardized to 20%(SDG).............100 mgD-calcium pantothenate (Vitamin B5) ............10.40 mgNiacinamide (Vitamin |
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